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Data extraction and quality assessment Two authors (BP and SO) independently extracted the data based on a predefined protocol and disagreements were solved by a third (JC)

doi: 10.1016/j.biopha.2020.110784 8 RodriguezRKrishnanY

Beyond Collagen: Comprehensive Matrix Components GHK-Cu stimulates comprehensive extracellular matrix component synthesis beyond just collagen: Elastin Increases 30% at all tested concentrations, providing crucial skin elasticity and preventing sagging Decorin Increases 302% at 1 nanomolar concentration

In all instances, there needs to be careful evaluation to determine the cause of the pigmentation [30, 34]

Considine, A.L

doi: 10.7326/0003-4819-141-11-200412070-00035 64