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Mescka CP, Rosa AP, Schirmbeck G, da Rosa TH, Catarino F, de Souza LO, Guerreiro G, Sitta A, Vargas CR, Dutra-Filho CS (2015c) L-carnitine prevents oxidative stress in the brains of rats subjected to a chemically induced chronic model of MSUD

First-line treatments for inducing remission typically include corticosteroids (prednisolone or budesonide) or exclusive enteral nutrition, particularly in children

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Chronic sleep deprivation or poor sleep quality impairs these restorative processes, potentially reducing glutathione synthesis capacity and increasing oxidative stress through various mechanisms including increased inflammatory signaling, impaired glucose metabolism, disrupted circadian rhythms affecting antioxidant enzyme expression, and increased psychological stress responses

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