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Amino Acids 51:139150 Bertinaria M, Rolando B, Giorgis M et al (2011) Synthesis, physico-chemical characterization and biological activities of new carnosine derivatives stable in human serum as potential neuroprotective agents

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These changes typically become noticeable within 8 to 12 weeks and continue to develop over the course of a full 3 to 4 month cycle