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Inhibiting the activity of system Xc affects GSH synthesis by inhibiting cystine absorption, leading to decreased GPX activity, reduced cellular antioxidant capacity, accumulation of lipid ROS, and ultimately oxidative damage and ferroptosis

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Furthermore, the tumor suppressor p53 serves as a critical node connecting these pathways as it can promote ferroptosis via SLC7A11 repression while simultaneously regulating apoptotic gene expression (144)

Conversely, oral formulations clear more rapidly, typically requiring only a 24-hour pause before most procedures

The rate of the primary composite outcome was significantly lower in the semaglutide group (6.6%) compared to placebo (8.9%) (hazard ratio [HR], 0.74

10.1016/j.carbpol.2009.12.027 132 ShiX.ChengW.WangQ.ZhangJ.WangC.LiM.et al (2021)