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While commercial sources of copper(I), such as cuprous bromide or iodide, can be utilized, the reaction is notably more effective when conducted with a combination of copper(II) and a reducing agent (e.g., sodium ascorbate) to generate Cu(I) in situ

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Some of the risk factors for this imbalance include (Jeanmonod, 2020): Birth control pills or hormone therapies that affect estrogen levels Antibiotic use Uncontrolled diabetes Pregnancy Immune system problems Treatments for yeast infections Candida species can live in the vagina and not cause symptomsthis is the case 10-20% of the time

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