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Leptin resistance where the hypothalamus no longer responds appropriately to adipokine signals is a hallmark of established obesity, as described in StatPearls (NCBI)

While there was a substantial increase over the ten-year period between 2012 and 2022, some evidence indicates that utilization has only continued to rise over the last two years, beyond the most recent claims data available

Similar to the carnivore diet, the keto diet relies on ketosis, a process that depletes glycogen stores so the body uses fat and ketones for energy

J Neurosci Res

Common side effects may include: Nausea Vomiting Lower appetite Early feelings of fullness GLP-1 drugs for weight management and blood sugar control may lead to low blood sugar levels (hypoglycemia)

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