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The method of embodiment 107, wherein the composition has an osmolarity from about 250 to about 320 mOsm/L

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A good example is a review published in 2003 in Endocrine Reviews , in which the authors note the importance of [growth hormone] and IGF systems in normal skin homeostasis. They specifically mention the role that growth hormone plays in collagen synthesis and the effect that IGF has on skin cell proliferation