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In the cytoplasm, Keap1 homodimer forms ubiquitin E3 ligase complex with cullin 3 (Cul3), which polyubiquitinates Nrf2 protein leading to its continuous proteasomal degradation ( Figure 3, right)

DOI: Published: Publisher Name: Humana, New York, NY Print ISBN: 978-1-0716-1189-0 Online ISBN: 978-1-0716-1190-6 eBook Packages: Springer Protocols