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A 2021 review published in Clinical Pharmacology & Therapeutics noted that most therapeutic peptides undergo proteolytic degradation rather than CYP450-mediated metabolism, making formal hepatic impairment studies less common in peptide drug development [4]

Much of this is simply a result of weight loss, although the data suggests the effects may be larger than explained by weight loss alone

doi: 10.3390/ijms22020860 148 ZhangMWuYGaoRChenXChenRChenZ

Background and aims: Hybrid Closed-Loop Systems (HCLS) may not perform optimally on postprandial glucose control