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Expired or improperly stored semaglutide may appear to "not work" when the real issue is degraded potency

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Currently, common clinical GLP-1RAs include exenatide and exenatide-LAR [34,35,36,37,38,39,40], lixisenatide [41,42,43,44], beinaglutide [45], liraglutide [46,47,48,49,50,51,52,53], semaglutide [54,55,56,57,58], albiglutide [59,60,61], dulaglutide [62,63,64], oral semaglutide [58, 65,66,67], PEG-loxenatide [68] and tirzepatide [68,69,70,71,72,73] (Table 1)

Regulatory Status Disclaimer Semaglutide, tirzepatide, PT-141, and thymosin alpha 1 have regulatory approval in at least one country for at least one indication

The medication is still suppressing appetite