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The complex interaction of factors such as insulin resistance, glucotoxicity and lipotoxicity contribute to the pathogenesis and coexistence of diabetes and metabolic-dysfunction associated steatotic liver disease (MASLD) in a reciprocal process of exacerbating the underlying conditions [9]

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In March 2024 the FDA approved semaglutide to help to lower the risk of cardiovascular death, heart attack and stroke in overweight or obese patients (Patchen)