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This is a later complication of under treated B12 deficiency and something that not many GP's will be aware of

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The supernatant was then analyzed by HPLC with a Rainin Econosphere ODS C18 column and an acetonitrile/water mobile phase containing 0.1% trifluoroacetic acid

Most patients report questions like Feeling worse after my B12 injection

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Hydroxocobalamin is the form the NHS uses because it lingers in the body longer than cyanocobalamin, and its pharmacology supports dosing intervals of up to three months once levels are stable