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Regulatory pathways and drugs associated with ferroptosis in tumors

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Unexpectedly, tumor burden was significantly reduced in mice with NOS2-deficient bone marrow chimers compared to the wild-type mice, suggesting that even though the number of M2 macrophages in iNOS-deficient TME is not affected, the immunosuppressive function of M2 macrophages may change

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Instead, they serve as a supportive therapy that enhances metabolic function, energy, and motivationmaking it easier to sustain lifestyle changes

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