Theoretical concerns similar to all GH-elevating interventions include potential effects on glucose metabolism, possible interactions with insulin signaling, and unknown long-term effects on cellular proliferation
Hyperplasia, hepatocellular (non-regenerative)no history or evidence of hepatocellular damage
doi: 10.1016/s0955-2863(03)00078-0
PEVs loaded with MCC950 (an NLRP3 inflammasome inhibitor) reduced atherosclerotic plaque formation and localized vascular inflammation [89,90,91,92], highlighting PEVs as biocompatible, autologous drug carriers [93]
Betaine supplementation attenuates atherosclerotic lesion in apolipoprotein E-deficient mice
FDA 503A timeline Late 2023: FDA placed MOTS-c on Category 2 of its 503A bulks list, the category for substances flagged for significant safety concerns