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Sobia Sadiq, triple board-certified in Internal Medicine, Endocrinology, and Obesity Medicine, and I have been prescribing GLP-1 medications for over a decade

The additional receptor activation means there are more pathways being affected simultaneously, which some people experience as more noticeable initial adjustment

if you become pregnant whilst on treatment, stop the medication and seek immediate medical and nutritional review [1] [25] Contact your GP urgently if you experience: Severe, persistent abdominal pain (with or without vomiting) which could indicate pancreatitis Upper-right abdominal pain, fever or jaundice which may suggest gallbladder disease Persistent nausea or vomiting preventing adequate nutrition Signs of dehydration (dark urine, dizziness, reduced urination) Unexplained symptoms such as jaundice, severe fatigue, or mood changes For people with diabetes: hypoglycaemia (low blood sugar) symptoms when taking insulin or sulfonylureas alongside GLP-1 therapy Regular monitoring throughout GLP-1 treatment should include periodic assessment of weight, body composition where possible, nutritional intake, and relevant blood markers

Fortunately, these side effects tend to be mild and can often be managed effectively with some lifestyle changes or over-the-counter remedies

N., Egan, L., Mamotte, C., Stokes, R., Gunton, J

Additionally, these medications can have a positive impact on metabolism