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The compounded damage severely limits the body's ability to produce energy, directly contributing to the hallmark symptom of post-exertional malaise (PEM), where even minor physical or cognitive exertion leads to a disproportionate and prolonged crash

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Results Interestingly, we found parental obesity to be associated with exacerbated unhealthy metabolic outcomes in the offspring with obesity, as mirrored in higher fasting insulin levels ( p = 2.8 10 8 ) and HOMA-IR scores ( p = 1.3 10 8 )