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Am J Physiol Gastrointest Liver Physiol (2012) 303(7):G77585.10.1152/ajpgi.00155.2012 152 KawamataYFujiiRHosoyaMHaradaMYoshidaHMiwaMet alA G protein-coupled receptor responsive to bile acids

From this experiment the increasing order of species tolerance was formulated which is S

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This version has two critical alterations: an extension of 13 amino acids at its N-terminus and, more importantly, the substitution of an Arginine for a Glutamic Acid at the third position

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Ultimately however the effort is worth it since you end up with a happy, hopefully symptom-free pet and reduced vet bills