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Avoid layering with: high concentrations of vitamin C, exfoliating acids (like AHA/BHA), or retinol in the same routine

Reflux, nausea, or abdominal symptoms that worsen after dose escalation and do not improve with basic plan changes

Previous research has demonstrated the efficacy of metformin as a radiosensitiser in models of colon cancer (30, 31)

Intramuscular (IM) Injections Intramuscular injections involve delivering the B12 injection directly into the muscle tissue

In mouse studies, researchers reported improved health markers rather than obvious toxicity, but mouse safety does not predict human safety

FDA-approved Crohn's treatments include biologic therapies (infliximab, adalimumab, vedolizumab, ustekinumab, risankizumab), JAK inhibitors (upadacitinib), corticosteroids for induction (budesonide, prednisone), and immunomodulators (azathioprine, methotrexate)