glutathione reactive oxygen species Sources of (ROS) and removal by superoxide 0604_article_05

View on PubMed Staresinic M, Petrovic I, Novinscak T, et al

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In pernicious anaemia, the immune system mistakenly attacks the gastric parietal cells that produce intrinsic factor, leading to B12 deficiency over time

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Low ROS levels activate cell survival signaling pathways, such as the unfolded protein response and Nrf2 pathways, whereas high ROS levels activate cell death signaling pathways, such as apoptosis and necroptosis pathways 43