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Hildebrand TM, Nunes Nesi A, Arajo WL, Braun HP

The synthesis of creatine from glycine in the skeletal muscle of fish may promote more efficient coupling with local energy metabolism for physiological functions (e.g., constant swimming [32]) when compared with terrestrial mammals and birds, because guanidinoacetate is formed and further converted into creatine in the same muscle fiber

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In addition, they are important for the embryonic and fetal development of brain networks

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