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In clinical trials, semaglutide produced roughly 15-17% average body weight reduction, while tirzepatide reached approximately 20-22% at the highest doses

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GLP-1 is produced by cells that express proglucagon (GCG)

doi: 10.1002/oby.23120

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Liraglutide showed greater reduction systolic blood pressure over diastolic in a 14 week study systolic blood pressure decreased by -5.2 mm Hg to -7.2 mm Hg compared to placebo with no difference in diastolic blood pressure