Consistent with these effects, GLP-1 RAs have been associated with substantial weight loss in clinical trials, leading to FDA approval of two of these agents liraglutide and semaglutide for chronic weight management in adults with obesity or with overweight and at least one weight-related comorbidity
In 2015, a study by Hayek et al
In theory, if food moves more slowly, the colon has more time to absorb water, potentially firming up stools
Eligibility is also more specific than some reports suggest
Instead, it helps move food through the digestive system, supporting regularity and overall gut health
Take home message Retatrutides side effects fall into three main groups: stomach and gut symptoms during dose increases, a heart-rate increase larger than other GLP-1 medications, and a skin sensation (dysesthesia) that emerged at higher doses in Phase 3