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Dietary Adjustments: Eating smaller, more frequent meals and avoiding high-fat or spicy foods can help reduce gastrointestinal discomfort and insulin resistance. Hydration: Staying hydrated during your treatment is essential, especially if you experience gastrointestinal adverse events like vomiting or diarrhea. Daily Exercise: Consistent activity like walking, jogging, or resistance training can strengthen bones and counteract both fat accumulation and bone density loss

Although the findings in the CANVAS trial showed a higher risk of amputation when taking canafliglozin compared to placebo [92], no significant difference in the risk of this complication was observed in the CREDENCE study [88]

Losing too much muscle mass can lead to: Decreased Strength Less muscle directly reduces strength, affecting both physical fitness and basic daily function

It may work as well as or even better than some other drugs

This macronutrient distribution supports satiety and metabolic health independent of supplement use

All adults had obesity and at least one autoimmune disease