Copper is a required cofactor for lysyl oxidase (connective-tissue crosslinking), for superoxide dismutase (antioxidant defense), and for enzymes that support angiogenesis, so a molecule that delivers copper in a controlled, cell-usable form has a coherent reason to influence tissue remodeling and vascular biology
Some of these signals include angiogenic growth factors, cell survival, turning on regenerative mechanisms, messenger RNA, and regenerative & healing signals
Burashnikov A, Sicouri S, Di Diego JM, Belardinelli L, Antzelevitch C (2010) Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation
(Basel) 11, 1057
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