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While it was originally developed to help manage type 2 diabetes, its ability to support weight loss led to the development of specific versions for chronic weight management

Why the Field Still Lacks Mechanistic Clarity The inability to establish a reproducible mechanistic model does not reflect a deficit of data, intelligence, or investment

No overseas uncertainty

Griffith DA, Edmonds DJ, Fortin JP, et al

NCT02637284 [online] Available at: [Accessed 20 Apr

In addition, as an inhibitor of HDAC, butyrate enhanced the transcriptional activity of HIF1, leading to higher expression of tight junction proteins to maintain intestinal barrier integrity (Fachi et al., 2019)