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Binge eating in BED may further be characterized by behavioral irregularities, such as eating rapidly or until feeling uncomfortably full, and results in marked distress or impairment

Besides improving glucose control, reducing body weight, and lowering arterial blood pressure (surrogate endpoints), the breakthroughs were the demonstration of a significant reduction in cardiovascular and renal events in patients with type 2 diabetes at high risk

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Neither timing changes the drug's biological action or final weight loss results

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Skipping meals can elevate stress hormones and intensify cravings later