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J Exp Bot 67:18531869

METAOD002: A Phase IIa (double-blind, placebo-controlled 4 4 Latin Square design) safety study with single doses (25, 50 and 100 g/kg AOD9604) administered intravenously to 23 healthy clinically obese males presenting with a BMI 35 kg/m 2

Luci S, Hirche F, Eder K

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This is why degradation appears to accelerate over time rather than proceeding linearly

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