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98 A single-center study from the USA evaluated 120 patients with IBD, of whom 60.8% were on an advanced therapy at baseline, and reported numerical reductions in HBI (3.523.18), modified Mayo score (1.611.54), and Simple Endoscopic Score for CD (SES-CD) (3.12.6) 1 year after GLP-1RA initiation
Author Contributions Conceptualization, M.K
From a safety perspective, the available semaglutide data indicate that adverse events are predominantly gastrointestinal, most commonly nausea, diarrhea, vomiting and constipation, without a clear thyroid-specific carcinogenic signal (193)
No head-to-head human RCT comparing the two for body composition outcomes exists