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Apr 2005;16(2):102-107
The effect of Nigella sativa Linn
A comprehensive panel of primary antibodies was used to detect various proteins: FOXO4, p53, Ser15-phospho-p53, p21 (cyclin-dependent kinase inhibitor 1A), p16 (cyclin-dependent kinase inhibitor 2A), 3-HSD, CYP11A1, CYP17A1 (cytochrome P450 family 17 subfamily A member 1), and several senescence-associated secretory phenotype (SASP) factors including IL-1, IL-1, IL-6, IL-10, TNF-, and TGF-
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When EPA alone was administered, significant increases in fatty acids derived from EPA, DHA and DPA, and significant decreases in stearate and arachidonate (20:4n-6) were observed (Table 3)
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