glutathione stress Oxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models Frontiers | Glutathione: A Samsonian

Indeed there are scientific articles that propose that supporting NAD with niacinamide (vitamin B3) may be helpful for sickle cell disease

Several hundreds of early SA-inducible genes were identified including two GSTs

With chronic alcohol use, the number of GABA receptors is increased, requiring more and more alcohol to create the same level of inhibition

[10] Low NAD+ levels have recently been connected with a number of age-related disorders and illnesses that are linked to increased oxidative/free radical damage, including diabetes, heart disease, vascular dysfunction, ischemic brain injury, Alzheimers disease, and vision loss

13(S)-Hydroxyoctadecadienoic Acid-PLPC

But its expensive ($150-300+ per session), requires ongoing clinic visits (1-3x/week), and has a half-life of only about 14 minutes