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Set realistic expectations - most people notice initial improvements around 2-4 weeks, with significant brightening effects appearing after 6-8 weeks of consistent use

It is highly cardioselective as it is predominantly deposited in the heart relative to other tissues and blood (Kuo et al., 1995)

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Glutathione plays an essential role in immune cell function, supporting the activity of natural killer cells and T-lymphocytes

Treatment response depends on deficiency severity, route of administration, underlying cause, patient age, concurrent medical conditions, and medication interactions