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Evaluation of a melanocortin-4 receptor (MC4R) agonist (setmelanotide) in MC4R deficiency
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Extracellular NAD + can enter cells via pore-forming channel connexin 43 (Cx43), a bi-directional NAD + transporter allowing exogenous NAD + transportation into the cell, and transportation out for utilization of NAD + by CD38 64
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