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While earlier compounds like semaglutide target a single receptor (GLP-1) and tirzepatide activates two receptors (GLP-1 and GIP), Retatrutide goes further by engaging three distinct pathways simultaneously: GLP-1, GIP, and glucagon receptors

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Successful application of various GLP-1 mimetics to treat type 2 diabetes mellitus (T2DM) and obesity highlights the clinical value of this group of drug targets 3

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