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While it is not yet fully understood how copper inactivates cells in a wet contact killing setting, even less is known about the mechanism behind dry contact killing (Santo et al., 2011)

Specifically, as an endogenous ligand of the aromatic hydrocarbon receptor, trans-3-indoleacrylic acid upregulates the expression of aldehyde dehydrogenase 1 family member A3, leading to increased production of NADH by utilizing retinol as a substrate

But when they become hyper-responsive, mast cells may release these chemicals too easily, too intensely, or at random

Pierzchliska et al., 2021), so much so in fact that it has been argued that Alzheimers may be just as much a vascular disease as a neurological one (DAndrea, 2016