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When to Consult Your Provider and Personalization Through Genetics Constipation lasting more than two weeks, accompanied by abdominal pain, blood in stool, or weight loss warrants medical evaluation

Biochem Biophys Res Commun 291:13021308 Yasuda N, Inoue T, Nagakura T et al (2002) Enhanced secretion of glucagon-like peptide 1 by biguanide compounds

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And we dont know the long-term consequences these drugs might have for healthy-weight people who take them for weight loss