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The Bottom Line GLP-1 drugs can benefit older adults with obesity, type 2 diabetes, or elevated cardiovascular risk

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Food and Drug Administration (FDA) and World Health Organization (WHO) have warned about unapproved injectable products

9 This paper presents a detailed overview of the biomarker function of TMAO in the gut-organ axis, as well as the regulation mechanism of TMAO on the gut-organ axis, particularly in relation to the crosstalk mechanisms involved in cell death

GDMT for HFrEF typically includes evidence-based beta-blockers, angiotensin receptor neprilysin inhibitors (ARNIs), angiotensin receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, mineralocorticoid receptor antagonists (MRA), and sodium-glucose cotransporter 2 inhibitors (SGLT2is), particularly in patients with obesity or T2DM [53]