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There are multiple drugs producing clinically relevant weight loss 9 , including semaglutide (S)a long-acting glucagon-like peptide-1 (GLP-1) 10 analogue and cagrilintide (C)a long-acting amylin analogue 11

HT affects approximately 12% of the general population and significantly impacts quality of life, as thyroid hormones regulate basal metabolic rate and influence multiple organ systems (Wroska et al., 2024)

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Comprehensive medical evaluation ensures safety and appropriateness

Phase 3 TRIUMPH-4 demonstrated 28.7% mean weight loss at 68 weeks with the 12 mg dose, confirming the exceptional Phase 2 results (24.2% at 48 weeks