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These compounds are highly lipophilic, and for this reason, accumulate preferentially in the adipose tissue [240]

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For instance, generally used tyrosine kinase inhibitors (TKIs) for systemic treatment including sorafenib and lenvatinib, in combination with ICIs including nivolumab and pembrolizumab have been approved for the treatment of advanced HCC because of their noteworthy antitumor efficacy (Lee et al., 2022)