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The IL-1 signaling pathway is implicated in acute doxorubicin-induced cardiotoxicity, with increased expression of IL-1, IL-1Ra, and IL-1RI correlating with cardiac damage [87]
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Amylin, an anorexic neuroendocrine hormone co-secreted with insulin, is deficient in individuals with diabetes and plays an important role in postprandial glucose homeostasis, with additional potential cardiovascular and neuroprotective functions
This overlap suggests that FOXO4s activation by oxidative stress and inflammation might follow similar mechanisms, pointing to a broader role of FOXO4 in stress and immune response contexts
The metal chelating capacity was significant as it reduced the concentration of the catalyzing transition metal in lipid peroxidation
