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The oxidation of pyruvate via the PDHc is highly exergonic with a free energy change on the order of 33 to 37.5 kJ/mol (8 to 9 kcal/mol)

& McGoldrick, M

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Moreover, during oxidative stress GSSG can also be exported from the cytosol either to the exterior or, in yeast, to the vacuole to maintain a reducing cytosolic environment (Ballatori et al , 2009