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Starting with one capsule daily instead of the recommended two and gradually increasing over a week can minimize this adjustment period

In a cervical cancer cell line (HeLa), the compound reduced cell proliferation in a concentration- and time-dependent way and lowered expression of phospho-Akt and SIRT1, two proteins tied to tumor progression, while a non-cancer reference cell line was less affected

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doi: 10.1002/cber.19671000806