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By concurrently modulating metabolic dysfunction and inflammatory signaling, GLP-1RAs could potentially reduce the required doses of biologics or other immunosuppressive therapies, thereby minimizing treatment-related toxicity while improving overall disease control

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2 Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

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47,48 These synthetic protein preparations exhibit partial or complete amino acid sequence homology with endogenous GLP-1, rendering them resistant to degradation which resulting in a prolonged half-life and heightened biological activity