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And alcohol is a major toxin

Individuals with reduced activity of the DHFR enzyme, which is responsible for the first step in folic acid metabolism, may be less able to convert folic acid efficiently

doi: 10.3389/fendo.2019.00389 30 ReinehrTRothCLEnrioriPJMasurK

However, some studies have shown that Dex has an effect on the cardiovascular system and could be responsible for lowering the heart rate and blood pressure, while the effect on the respiratory rate and saturation is less common ( This study had some limitations

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Recent reports show that all patients present with fever