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Hormonal Issues : Certain hormonal conditions, particularly those involving the adrenal glands can cause the skin and lips to turn darker

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Alcohol use disorder (AUD) is defined as pathologic consumption of alcohol leading to impaired daily functioning

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In the spinal ossification centers of igf-1 null animals, the switch from type II collagen to type X collagen expression during chondrocyte differentiation is perturbed as shown by an increased number of type II collagen-expressing prehypertrophic chondrocytes and persistent type II collagen expression in hypertrophic chondrocytes

Human congenital perilipin deficiency and insulin resistance