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NICE guidelines recommend lifestyle modifications as foundational therapy, but many patients require additional pharmacological treatment to achieve glycaemic targets or clinically significant weight loss

The approval is based on clinical criteria embedded in coverage policies that are largely PBM-proprietary and not publicly available

It has been conjectured that ADC aggregates are sequestered in the liver, leading to hepatotoxicity (8)

Hathaway JT, Shah MP, Hathway DB, et al

While we have observed a direct detrimental effect of a cholesterol-enriched diet on islet GLP-1R cAMP outputs, we cannot rule out that the reduced receptor capacity to lower blood glucose levels following cholesterol loading might encompass further negative effects of high cholesterol on GLP-1R downstream signalling

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