Available at: [accessed March 2026]. The SELECT Trial: A Brief Summary
In the absence of genetic defect in SSTR2, SSTR5, and DRD2 genes, alterations have been reported in molecules involved in the intracellular signal transduction pathway specific of these receptors, and in the regulation of receptors expression
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Considering that OSAS patients often present with multiple comorbiditiessuch as hypertension, coronary artery disease, and diabetesfurther large-scale, long-term follow-up studies are needed to clarify tirzepatides safety in multimorbid populations (63, 64)
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By virtue of their multi-target, low-toxicity, and system-level regulatory properties, natural products represent promising adjuvant agents for combination immunotherapy strategies aimed at enhancing efficacy, mitigating resistance, and improving long-term clinical outcomes