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Before each injection, check that the solution is clear and colourless (or slightly yellowish for some products), free from particles or cloudiness, within its expiry date and in-use period, and that the pen is undamaged

Unrepaired 8-oxo-G is potentially one of the most mutagenic lesions, since it pairs with A, inducing G T transversions 40 , and represents a prominent candidate to be a marker of ROS-induced mutagenesis and tumorigenesis 41

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