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Abstract Background Melanosis coli is characterized by brown mucosa with pigmentation

Phase I and II trials subsequently confirmed the predictable pharmacokinetics, dose-proportional efficacy, and manageable tolerability profile of semaglutide, allowing clear selection of therapeutic doses (0.5 mg and 1 mg s.c

In response to 16 days of supplementation with 3.4 g/d, L-citrulline significantly increased plasma citrulline, arginine, and nitrite levels, and also increased muscle oxygenation

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