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In randomised trials, NAC has improved ovulation rates significantly more than placebo and has been a useful adjuvant when added to clomiphene or letrozole, particularly if you haven't responded to ovulation-induction medication alone

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Flavonoids increase the serum levels of FSH, and sharply decrease the serum levels of LH, testosterone and insulin in the PCOS-insulin resistant rats via partly inhibiting the activation of JAK2/STAT3 pathway, partially up-regulating the IL-6 expression and down-regulating the suppressor of cytokine signalling 3 (SOCS3) expression in ovaries of PCOS rats (106)