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Abbreviations GST: Glutathione s-transferase GSH: Reduced glutathione GFP: Green fluorescent protein BF: Brightfield PEGDA: Poly(ethylene glycol) diacrylate
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Although clinical trials specifically for MASH have not yet been conducted, preclinical studies confirm significant regulatory effects on hepatic metabolism, providing a novel strategy for targeted MASH therapy and supporting future translational research
For in vivo administration, mice received AAV9-U6-shCA9 or AAV9-U6-shNC via intrarectal injection through the tail vein at a dose of 10 11 vg/mouse in a volume of 100 l before DSS treatment
The Bottom Line Managing MTHFR mutations requires a personalized approach that combines lifestyle, dietary, and supplementation strategies
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